The study, “Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring,” published in Frontiers in Immunology (2022), does not directly investigate low-intensity infrasound or its effects on tissue healing. Instead, it explores the role of mechanotransduction—the process by which cells convert mechanical stimuli into biochemical signals—in skin wound healing and hypertrophic scar (HTS) formation. It highlights that mechanical forces significantly influence healing outcomes, with excessive tension promoting HTS and tension-offloading strategies reducing scarring. Mechanotransduction pathways, such as Integrins-FAK and YAP/TAZ, are critical in regulating cellular responses like proliferation, differentiation, and extracellular matrix (ECM) remodeling. The study suggests that controlled mechanical environments, achieved through interventions like silicone gel sheets or microneedles, can mitigate fibrosis and enhance regeneration, providing a basis to consider how gentle mechanical stimuli, such as low-intensity infrasound, might influence healing.

While not directly addressing therapeutic infrasound, this study implies that very low-level mechanical forces, as provided by low level infrasound, if appropriately calibrated, can potentially accelerate tissue healing by engaging mechanosensitive pathways without triggering profibrotic responses. For instance, gentle stimulation might modulate Integrins-FAK signaling to promote balanced wound closure, similar to the effects of FAK inhibitors that reduce scarring and enhance regeneration in animal models. Low-intensity infrasound can potentially mimic tension-offloading strategies by providing rhythmic, non-invasive mechanical cues, potentially supporting processes like keratinocyte migration or angiogenesis during the proliferative phase. Thus, this study provides a foundation whereby the accelerated tissue healing effects observed with low frequency infrasound might be better understood.