This study demonstrates that low-intensity infrasound (4-20 Hz, 79-86 dB) applied for 60 minutes enhances the proliferation of bone marrow mesenchymal stem cells (BMSCs) in vitro by upregulating the Notch signaling pathway, specifically increasing mRNA and protein expression of Jagged1, Notch1, and Hes1, while inhibition of this pathway with a γ-secretase inhibitor negates these effects. For medical professionals, these findings suggest that low-intensity infrasound could be a promising non-invasive mechanical stimulus to boost BMSC proliferation for regenerative medicine applications, such as tissue repair or bone regeneration, although further research is needed to elucidate specific mechanisms and optimize clinical protocols.

Owners of the Infrasound 8 device used in this study or a later version like the CHI Palm might use it to support the healing of injuries involving bones or tissues by encouraging the growth of special cells that help repair the body. Applying the device at low intensity and on the acute setting (signal 3 on the Infrasound 8) could lead to faster cell growth, potentially helping the body rebuild damaged areas more quickly. Owners might expect improved recovery from injuries like broken bones or tissue damage. More studies are needed to confirm the best way to use the device and ensure it works safely for people.